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AMINO ACID CONFIGURATION IN P53 ...
... May increase the risk of cervical cancer
According to findings published in Nature (1998;393-229-234), HPV-infected women who carry two copies of a certain mutation of the p53 gene are seven times as likely to develop cervical cancer as infected women who have one copy of the variation. Previous reports have linked many types of cancer to mutations in p53, which in its normal form is know as the 'tumor-suppressor' protein because of its ability to protect against cancer cell growth.
The new study is the first to document a genetic susceptibility to cervical cancer. When a woman is infected with certain types of HPV, a viral protein called E6 bonds with p53 and causes it to deterio-rate, increasing the risk for cervical can-cer, according to the report.
Two copies of arginine-encoded gene increase risk.
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