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ESTROGEN REPLACEMENT THERAPY (ERT) AND MENTAL PERFORMANCE

Premarin, a mixture of ten different estrogenic hormones, gets its name from pregnant mare's urine, from which it is derived. A major component of Premarin, Equilin, with a low affinity for breast and uterine receptors, may be the key to preserving cognitive function not only in women but in men as well. Equilin increased the number of neurites and the number of nerve branches in the frontal, parietal, and temporal lobes. In contrast, 1 7Beta-estradiol inhibited temporal lobe nerve-cell growth. Dr. Roberta Diaz Brinton reported the results of these studies, at the annual meeting of the Society for Gynecological Investigation.

Dr. Brinton, a molecular pharmacologist, at UCLA, also reported at the International Alzheimer's Conference in Osaka, Japan, that Equilin was even more effective than estrogen in stimulating nerve-cell growth and branching in the brain. The greater the number of connections between brain cells, the better it can process information. In the journal of the American Geriatrics Society, July 1996, Dr. Stanley Birge, a geriatrician at the Washington University School of Medicine in St. Louis summarized the findings that support a role for estrogen as a preventive and treatment for dementia.

OB GYN News, 6/96



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