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IS YOUR BRAIN ON ESTROGEN?

Estrogen Enhances Brain Function By Improving Cerebral Vascular Perfusion

After 6 weeks of estrogen replacement. Therapy (Premarin 2.Smg orO.62S) dramatic improvement in cerebral blood flow was demonstrated on single photon emission computed sonography (SPECT) scans, according to Dr. Robert Green of California. The greatest increase in blood flow was at the level of cerebral cortex where the SPECT scan demonstrated a mean increase of 9.2 ml. of blood per 100g of brain tissue per minute, or a mean increase of 22% over baseline. The brain function tests correlated with imaging findings. The greatest improvement s were noted on tests for short term memory and verbal memory, which is consistent with the cerebral blood flow studies. It seems that estrogen enriches performance of the hippocampus, which is abundant in estrogen receptors and plays an important role in learning and memory.

It also increases acetyltransferase and enhances synaptogenesis in memory centers of the brain. The research was carried out at Harbor - UCLA Medical Center in Torrance, CA.

OB/GYN News 06/1996  



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