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BREAST-OVARY CANCER SYNDROME

...is associated with mutations in BRCA1 and BRCA2 genes located on chromosomes 17 and 18, respectively. Patients with mutations in BRCA1 are at risk for development of breast, ovary and pancreatic cancers, with women carrying certain BRC1 mutations anticipating a 95% risk of developing breast cancer and an approximate 50% risk of developing ovarian cancer by age 70. Patients with mutation of BRCA2 gene have a somewhat lower cancer risk.

Menopausal Medicine, 5, 2, 1997

 



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