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FIXING FAULTY GENES

A British team of scientists have  discoverd how defective genes could be  removed from sperm and egg, raising the  prospect that scores of hereditary diseases  could be eliminated from mankind.  This means that faulty genes responsible  for diseases such as cystic fibrosis, muscular  dystrophy, and certain cancers  could be replaced by healthy ones before  an egg is fertilized.

Because such genetic changes are done  before a sperm fertilizes an egg, the  "new" genes will pass to subsequent  generations, permanently altering a  family's genetic inheritance. There are  more then 4,000 hereditary diseases  caused by defects in single genes.

The key protein that controls genetic  shuffling in the ovaries and testes has  been identified . The protein, called RAD  51, can be used to "stitch" a healthy copy  of a gene ino the position of a defective  gene on a chromosome of a human sperm  or egg. The researcher at the Imperial  Cancer Resrach Fund's Clare Hall Lab in  Hardfordschire, U.K. believe the breakthrough  will improve the prospect of safe  gene therapy on sperm and eggs. Twenty  years from now it will be fairly routine.


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