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WEIGHT-LOSS BREAKTHROUGH

Online version of the Journal Nature

Scientists say a brain enzyme that monitors energy in cells also appears to regulate appetite and weight, a discovery that could lead to new treatments for obesity.

The enzyme is known as AMP-activated protein kinase, or AMPK. Its activity is regulated by the hormone leptin, which previously was linked to appetite suppression.

Harvard researchers found in experiments with mice that when AMPK was inhibited, the animals ate less and lost weight. When the levels were boosted, the mice ate more and gained weight.

Barbara Kahn, the lead author, said the study may help overweight people.


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